Tag Archives: TBI

ICHIRF: PFA To Support Concussion in Sport Project

The Concussion Foundation has announced that the PFA (Professional Footballers Association) has donated funds to support the Concussion in Sport study set up by ICHIRF (International Concussion & Head Injury Research Foundation). This project is looking at the long-term effects of concussion in men and women who have competed in impact sports and the support of the PFA will ensure that retired footballers are now included in this study.

Dr Michael Turner, Director of Concussion in Sport, says: “The support of the PFA is a major step forward and will ensure that our research now includes retired footballers. This will broaden the scope of the ICHIRF project and we are extremely grateful to Gordon Taylor and John Bramhall for their confidence in our ground-breaking study”

The ICHIRF project is part of a multi-national collaboration between concussion research centres in Australia, Switzerland and the USA. This independent research seeks to establish whether retired sportsmen and sportswomen have an increased incidence of, or suffer an earlier onset of neuro-degenerative disorders such as Parkinson’s Disease, Alzheimer’s Disease and the condition currently described as chronic traumatic encephalopathy (CTE).

ICHIRF is also looking for control subjects who have never suffered a concussion and further information can be found at www.ichirf.org or by contacting Pippa Theo at the ICHIRF Office, pippa@ichirf.org 0207 935 3015.

 

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Judge Grants Summary Judgment to Arena Football One

(Editor’s Note: What follows is an excerpt from the recent issue of Concussion Litigation Reporter. To read the full article, please subscribe at http://concussionpolicyandthelaw.com/subscribe/)

A federal judge from the Eastern District of Louisiana has granted partial summary judgment to Arena Football One (AFO) in a case in which it was sued by a player, who suffered multiple concussions while playing in the league.

In so ruling, the court relied on two pivotal findings; that the plaintiff had failed to demonstrate that AFO intended for the plaintiff to get hurt and second that there is no direct nexus between playing football and suffering a concussion.

By way of background, plaintiff Lorenzo Breland alleged that he sustained his initial concussion while playing for the Tulsa Talons in 2011, which is part of the AFO.

After the team doctor diagnosed Breland with a concussion, he alleged the team encouraged him to return and he started the following game. Subsequently, he played for the New Orleans Voodoo. The plaintiff alleged that he sustained a severe blow to the head during a game on April 11, 2014, which caused a second concussion. Breland claimed that, after the 2014 incident, he received inadequate medical attention and care and was pressured to return to playing football before he was fully rehabilitated. He alleged that, after complaining to the coach about his continued health problems, he was sent to a speech pathologist. The plaintiff alleged that this head injury caused him to remain bedridden for six weeks, and that he was ultimately suspended from the league and cut from the Voodoo. Breland claimed that the second concussion ended his career, and the defendants did not pay for his ongoing medical care or rehabilitation to allow him to return to play in a healthy manner. The plaintiff alleged that he continues to suffer long-term problems, including dizziness, memory loss, headaches, weight loss, neck aches and fatigue, and that he faces an increased risk for future disorders as a result of the injuries.

As part of his lawsuit, he asked for damages, past and future medical expenses related to the concussions, and medical monitoring to facilitate the diagnosis and treatment of future disorders caused by the injuries. The plaintiff claimed …

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How Blows to the Head Cause Numerous Small Swellings Along the Length of Neuronal Axons

Researchers from The Ohio State University have announced they have discovered how blows to the head cause numerous small swellings along the length of neuronal axons. The study, “Polarity of varicosity initiation in central neuron mechanosensation,” which will be published June 12 in The Journal of Cell Biology, observes the swelling process in live cultured neurons and could lead to new ways of limiting the symptoms associated with concussive brain injuries.

Mild traumatic brain injuries, or concussions, cause a variety of temporary symptoms, including headache, nausea, and memory loss. But the effects of concussive impacts on neurons in the brain are poorly understood. One such effect is the development of “axonal varicosities,” small, bead-like swellings that appear along the length of neuronal axons, which are the parts of neurons that transmit electrical and chemical signals to neighboring nerve cells. Similar swellings are seen in the degenerating axons of Alzheimer’s and Parkinson’s patients.

Chen Gu and colleagues at The Ohio State University discovered that they could induce the formation of axonal varicosities in hippocampal neurons grown in the lab by “puffing” them with bursts of liquid from a small pipette. The pressure exerted by these puffs was similar to the forces neurons might experience after a blow to the head.

The axonal varicosities formed rapidly, particularly in younger neurons where they swelled up within 5 seconds of being puffed. A surprise to the researchers was that the varicosities disappeared several minutes after puffing, indicating that they are not a sign of irreversible axon degeneration.

Gu and colleagues could also induce axonal varicosities by repeatedly puffing cultured neurons with shorter bursts of liquid, mimicking the effects of repetitive, subconcussive impacts. Accordingly, the team also saw axonal varicosities in the brains of mice subjected to repeated light blows to the head.

The researchers found that puffing activated a mechanosensitive channel protein called TRPV4, which is enriched in the membrane of neuronal axons and allows calcium ions to enter the cell. Inhibiting this channel blocked the formation of axonal varicosities.

After entering axons through activated TRPV4 channels, calcium ions appear to disrupt the microtubule cytoskeleton by inhibiting a microtubule-stabilizing protein called STOP. This interrupts the transport of cellular materials along axonal microtubules, causing these materials to accumulate at several points along the axon where they may give rise to varicosities.

Older neurons, which are more resistant to the effects of puffing, express lower levels of TRPV4 and higher levels of STOP. “It will be interesting to determine whether these factors make a mature brain more resistant to mild traumatic brain injury than a young brain,” says Gu.

Puffing didn’t induce varicosities along the lengths of dendrites, the parts of neurons that receive chemical signals from neighboring nerve cells. Instead, the researchers found that dendritic, but not axonal, varicosities could be induced by prolonged treatment with glutamate, an excitatory neurotransmitter that is released from damaged axons.

“Taken together, our findings provide novel mechanistic insights into the initial stage of a new type of neuronal plasticity in health and disease,” says Gu, who points out that axonal varicosities have also been observed in healthy brains where neurons may respond to mechanical signals from their environment. “This process may therefore play a key role in neural development and central nervous system function in adults, as well as in chronic brain disorders and various acute brain injuries.”

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